13 Dog Breeds At The Highest Risk For Genetic Disorders

Aug 31, 2025byMichael Tremblay

Our canine companions bring endless joy to our lives, but some breeds face more health challenges than others. Certain dogs have a higher chance of inheriting specific conditions due to their genetic makeup and breeding history.

Understanding these risks doesn’t mean avoiding these wonderful breeds altogether, rather, it helps potential dog parents prepare for special care their furry friends might need throughout their lives.

This article is based on information from reliable online sources and is intended for general knowledge only. Health risks can vary between individual dogs.

1. German Shepherd

German Shepherd
Image Credit: © Yan Krukau / Pexels

Loyal protectors with intelligence that amazes, German Shepherds unfortunately carry a significant risk of hip and elbow dysplasia. These painful joint conditions develop when the ball and socket don’t fit properly, causing grinding and eventual deterioration.

Many also suffer from degenerative myelopathy, a progressive spinal cord disease leading to paralysis. Regular exercise without overexertion, maintaining healthy weight, and joint supplements can help manage these risks in these devoted companions.

2. Bulldog

Bulldog
Image Credit: © Sarah Blocksidge / Pexels

Those adorable wrinkles and pushed-in faces come at a steep health cost. Bulldogs struggle to breathe properly due to their shortened airways. A condition called Brachycephalic Airway Syndrome that can cause overheating, sleep apnea, and exercise intolerance.

Did you know Bulldogs typically can’t give birth naturally? Their broad heads and narrow hips make cesarean sections necessary for nearly all pregnancies. Add in common skin fold infections and joint problems, and these lovable couch potatoes require specialized veterinary attention throughout their lives.

3. Golden Retriever

Golden Retriever
Image Credit: © Bruno Cervera / Pexels

Behind those soulful eyes and wagging tails lurks a heartbreaking vulnerability. Golden Retrievers face an alarming cancer risk, with over 60% developing some form during their lifetime, particularly hemangiosarcoma and lymphoma.

These sunny-natured companions also commonly battle hip dysplasia and elbow problems that can limit mobility. Heart conditions like subvalvular aortic stenosis affect many Goldens too. Despite these challenges, their unwavering friendliness and devotion make them one of America’s most beloved breeds.

4. Dachshund

Dachshund
Image Credit: © Pavel Danilyuk / Pexels

Those adorably long bodies make Dachshunds particularly vulnerable to intervertebral disc disease (IVDD). Imagine the spinal discs as tiny cushions between vertebrae. In Dachshunds, these cushions can rupture or herniate, causing extreme pain, mobility issues, or even paralysis.

Approximately 25% of Dachshunds will suffer from this condition during their lifetime. Their short legs also contribute to patellar luxation (slipping kneecaps) and obesity risks. Careful handling, proper weight management, and avoiding jumping can help protect these spunky little hunters.

5. Pug

Pug
Image Credit: © Александр Македонский / Pexels

Those bulging eyes and wrinkled faces that make Pugs so endearing actually cause their most serious health problems. Their extremely flat faces restrict airflow, forcing many Pugs to breathe primarily through their mouths and struggle during even mild exercise or warm weather.

Their prominent eyes easily develop corneal ulcers or even pop out of socket during play. Pug Dog Encephalitis, a fatal brain inflammation, exclusively affects this breed. Despite these challenges, their comical personalities and affectionate nature continue winning hearts worldwide.

6. Labrador Retriever

Labrador Retriever
Image Credit: © Matthis Volquardsen / Pexels

America’s favorite family dog hides several genetic health concerns behind that happy-go-lucky demeanor. Exercise-induced collapse affects many Labs, causing them to suddenly lose coordination and collapse during intense activity, a frightening experience for both dog and owner.

Progressive Retinal Atrophy gradually steals their vision, while hip and elbow dysplasia can limit mobility. Many Labs also battle obesity that worsens joint issues. Regular eye exams, controlled exercise, and careful diet management help these lovable companions maintain their characteristic bounce and enthusiasm.

7. Cavalier King Charles Spaniel

Cavalier King Charles Spaniel
Image Credit: © Kelatout / Pexels

Those heart-melting eyes reflect this breed’s most devastating condition: nearly all Cavaliers eventually develop mitral valve disease, where heart valves gradually fail to close properly. By age 10, almost 100% show symptoms of this progressive heart failure.

Even more heartbreaking is syringomyelia, where the brain is too large for the skull, forcing spinal fluid into painful pockets in the spinal cord. Affected dogs scratch at their necks and cry out in pain. Early cardiac screening and MRIs help identify these conditions before they become debilitating.

8. Boxer

Boxer
Image Credit: © Laurence FUSCO / Pexels

Energetic and playful, Boxers face a concerning array of cancer risks that significantly shorten their lifespans. Mast cell tumors, lymphoma, and brain tumors develop at higher rates in Boxers than almost any other breed.

Arrhythmogenic Right Ventricular Cardiomyopathy (a heart condition specific to Boxers) can cause sudden death even in seemingly healthy young dogs. White Boxers often face hearing impairment or deafness. Despite these challenges, their unwavering loyalty and goofy personalities make the heartbreak worth it for devoted Boxer lovers.

9. Rottweiler

Rottweiler
Image Credit: © MART PRODUCTION / Pexels

These powerful guardians face a uniquely high risk of osteosarcoma: an aggressive bone cancer that typically affects their limbs. Larger Rottweilers seem particularly vulnerable, suggesting their rapid growth may contribute to cancer development.

Hip and elbow dysplasia plague many Rotties, causing painful arthritis as they age. Cruciate ligament tears occur frequently, often requiring expensive surgery. Despite these challenges, responsible breeding programs work to reduce these risks while preserving the loyal, confident temperament that makes Rottweilers exceptional family protectors.

10. Great Dane

Great Dane
Image Credit: © Efrem Efre / Pexels

Gentle giants with heartbreakingly short lives, Great Danes face several life-threatening conditions linked to their massive size. Bloat (where the stomach twists on itself) can kill within hours without emergency surgery, affecting nearly 40% of these giants.

Dilated cardiomyopathy weakens their massive hearts, often leading to sudden death. Their rapid growth contributes to crippling joint problems and wobbly gaits. Many owners opt for preventative stomach tacking surgery and careful feeding routines to reduce bloat risk in these sweet-natured companions.

11. Shar Pei

Shar Pei
Image Credit: © Engin Akyurt / Pexels

Those trademark wrinkles create a perfect environment for chronic skin infections. The deep folds trap moisture and bacteria, leading to painful, smelly conditions requiring constant cleaning and sometimes antibiotics.

More concerning is Shar-Pei Fever, a condition unique to this breed causing recurrent fevers and swollen hocks. This mysterious ailment can eventually lead to kidney failure. Their tiny ear canals also become easily infected. Regular skin fold cleaning, ear maintenance, and watching for fever symptoms help manage these distinctive dogs’ special needs.

12. Dalmatian

Dalmatian
Image Credit: © Helena Lopes / Pexels

Those iconic spots hide a unique metabolic quirk. Dalmatians process uric acid differently from other dogs, making them extremely prone to bladder stones that can block urination and require emergency surgery.

Approximately 30% of Dalmatians are born partially or completely deaf due to a gene linked to their distinctive white coat. This hearing loss contributes to their sometimes skittish or unpredictable behavior. Special low-purine diets, frequent bathroom breaks, and hearing tests for puppies help manage these distinctive challenges.

13. Doberman Pinscher

Doberman Pinscher
Image Credit: © RDNE Stock project / Pexels

Sleek and athletic, Dobermans hide a devastating heart condition beneath their powerful exteriors. Dilated cardiomyopathy affects over 50% of these dogs, often causing sudden death with no warning signs.

Von Willebrand’s disease, a blood clotting disorder, makes even minor injuries potentially dangerous. Dobermans also face higher risks of cervical vertebral instability (wobbler syndrome) and narcolepsy. Regular cardiac screening, including Holter monitors and echocardiograms, helps detect heart problems early in these loyal, intelligent guardians.

Michael Tremblay
byMichael Tremblay

A nature enthusiast from Montreal with a background in wildlife photography. Michael writes about wildlife, conservation efforts, and the beauty of animals in their natural habitats.