7 Predators That Hunt Rattlesnakes And 6 That Are Immune To Their Venom

Oct 3, 2025bySarah McConnell

Rattlesnakes are often seen as fearsome hunters, but in the natural world even they have enemies. A surprising number of animals prey on rattlesnakes, from birds of prey that swoop down from above to mammals that rely on speed and cunning.

Just as fascinating are the species that can withstand rattlesnake venom, allowing them to survive encounters that would be fatal to most creatures.

Learning about these predators and immune animals shows how rattlesnakes fit into a larger web of survival and balance in the wild.

This article is for general knowledge only and is based on information from online sources. Wildlife behaviour and predator-prey relationships can vary by region and circumstance.

1. King Snakes

King Snakes
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King snakes earned their regal name through their remarkable ability to prey on other snakes, including venomous rattlesnakes. Their powerful constriction technique allows them to squeeze their prey until it can no longer breathe.

What makes king snakes truly impressive is their natural immunity to rattlesnake venom. Their specialized blood proteins neutralize the toxic compounds that would kill other animals. King snakes will actively track and hunt rattlesnakes, using their keen sense of smell to locate their slithering prey.

2. Roadrunners

Roadrunners
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Not just cartoon characters, roadrunners are fierce rattlesnake hunters in real life. These speedy birds dart in with lightning-quick reflexes, grabbing snakes by the head before they can strike.

A roadrunner’s hunting strategy involves repeatedly slamming the snake against rocks or hard ground, effectively stunning it. Their thick feathers provide some protection against accidental bites. After killing a rattlesnake, the roadrunner may consume it whole or, if too large, in manageable pieces over several meals.

3. Hawks And Eagles

Hawks And Eagles
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From high above, hawks and eagles spot the distinctive patterns of rattlesnakes moving across open terrain. Red-tailed hawks and golden eagles are particularly known for their rattlesnake-hunting prowess.

These birds swoop down at incredible speeds, using their powerful talons to grab the snake behind the head. Their thick leg scales provide natural armor against potential bites. Once secured, they’ll either consume smaller snakes immediately or carry larger ones to their nests to feed their young.

4. Coyotes

Coyotes
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Coyotes approach rattlesnakes with caution and cunning. Their hunting technique involves quick pounces followed by rapid head shakes that snap the snake’s spine before it can deliver a venomous bite.

Though not immune to venom, coyotes have developed remarkable reflexes and hunting strategies. They’re most likely to hunt rattlesnakes during dawn and dusk when the reptiles are less active due to cooler temperatures. For coyotes, rattlesnakes represent both a potential meal and a dangerous adversary requiring respect.

5. Wild Boars

Wild Boars
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Wild boars possess thick skin and a substantial layer of fat that provides natural protection against rattlesnake bites. Their tough hide can prevent fangs from penetrating deeply enough to deliver a lethal dose of venom.

These omnivorous animals will eagerly consume rattlesnakes when encountered. A wild boar’s hunting strategy involves charging and trampling snakes with their hooves, then using their tusks to flip and tear apart their prey. Their aggressive nature and physical advantages make them formidable rattlesnake predators.

6. Badgers

Badgers
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Badgers bring a unique combination of speed, strength, and thick fur to rattlesnake encounters. These stocky mammals can withstand some venom due to their dense coat and loose skin, which limits venom spread.

A badger’s hunting strategy involves digging out snake dens and catching rattlesnakes by surprise. Their powerful jaws deliver crushing bites to the snake’s head. Badgers have been observed storing rattlesnake carcasses in their burrows, suggesting they may cache these prey items for future meals.

7. Bobcats

Bobcats
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Bobcats employ stealth and patience when hunting rattlesnakes. These medium-sized wildcats carefully track their prey, watching for the perfect moment to strike with lightning-fast paw swipes.

Their thick fur provides some protection against bites, while their quick reflexes help them avoid strikes. Bobcats typically target the snake’s head, disabling it quickly to prevent counterattacks. Though not specialized snake hunters like some other animals, bobcats opportunistically prey on rattlesnakes when larger game is scarce.

8. Opossums

Opossums
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Opossums possess a remarkable superpower against rattlesnake venom. Their blood contains a protein called LTNF (Lethal Toxin-Neutralizing Factor) that neutralizes various snake venoms, making them practically immune to rattlesnake bites.

These nocturnal marsupials will readily consume rattlesnakes when encountered. An opossum’s slow metabolism actually helps it survive venomous bites by processing toxins gradually. Scientists study opossum blood proteins hoping to develop better antivenom treatments for humans bitten by venomous snakes.

9. Honey Badgers

Honey Badgers
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Honey badgers have earned their reputation for fearlessness through their remarkable resistance to snake venom. While not completely immune, they can withstand venom doses that would kill other animals their size.

Their tough, loose skin provides physical protection against bites. A honey badger might appear temporarily affected by venom but typically recovers quickly. Their aggressive approach to rattlesnakes involves direct attacks targeting the head. This combination of venom resistance and offensive strategy makes honey badgers formidable rattlesnake adversaries.

10. Hedgehogs

Hedgehogs
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Hedgehogs possess a natural resistance to various snake venoms, including those from rattlesnakes. Their specialized proteins bind to venom components, rendering them harmless before they can cause damage.

When confronting a rattlesnake, a hedgehog will roll into a defensive ball, presenting its spiny exterior. The hedgehog can then launch surprise attacks, targeting the snake’s head. Their small size belies their effectiveness against venomous reptiles. European hedgehogs have been documented successfully hunting and eating venomous snakes despite their seemingly vulnerable appearance.

11. Mongoose

Mongoose
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The mongoose’s legendary snake-fighting abilities aren’t just folklore. These quick mammals possess specialized acetylcholine receptors that prevent rattlesnake venom from binding effectively to their cells.

A mongoose attacks with incredible speed, darting in and out while avoiding strikes. Their agility allows them to tire the snake before delivering a fatal bite to the head. Mongooses teach their young how to fight snakes, passing down hunting techniques through generations. This combination of physical adaptation and learned behavior makes them exceptional snake hunters.

12. Ground Squirrels

Ground Squirrels
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California ground squirrels have evolved a fascinating defense against their rattlesnake predators. Their blood contains proteins that can neutralize rattlesnake venom, offering significant protection during encounters.

These clever rodents will even chew on shed rattlesnake skin and then lick their fur, applying snake scent as camouflage. Mother squirrels with pups show higher venom resistance than those without young. Ground squirrels will sometimes harass rattlesnakes by kicking dirt at them and performing tail-flagging displays to deter attacks.

13. Pigs

Pigs
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Domestic pigs share their wild cousins’ natural resistance to rattlesnake venom. Their thick skin, substantial fat layer, and specialized blood proteins work together to neutralize venom effects.

Historically, farmers in snake-prone areas would allow pigs to roam fields before harvest to clear them of rattlesnakes. A pig’s strong neck muscles prevent venom from spreading quickly through their system if bitten. Their natural foraging behavior leads them to actively root out and consume snakes they encounter, making them effective rattlesnake controllers.